منابع مشابه
dsRNA in immunometabolism
The worldwide prevalence of obesity has reached pandemic proportions, and with it have come other associated metabolic diseases, such as insulin resistance and type 2 diabetes (T2D). Intensive research has identified the frequent coexistence of obesity with a state of inflammation in metabolic tissues such as adipose tissue and liver [1]. Multiple inflammatory and stress responses are evoked in...
متن کاملImmunometabolism in Tuberculosis
Immunometabolism, the study of the relationship between bioenergetic pathways and specific functions of immune cells, has recently gained increasing appreciation. In response to infection, activation of the host innate and adaptive immune cells is accompanied by a switch in the bioenergetic pathway from oxidative phosphorylation to glycolysis, a metabolic remodeling known as the Warburg effect,...
متن کاملImmunometabolism: Molecular Mechanisms, Diseases, and Therapies
1 Immunometabolism Research Group, Institute of Biomedical Sciences, University of São Paulo (USP), 05508-000 São Paulo, SP, Brazil 2 Exercise and Immunometabolism Research Group, Department of Physical Education, Universidade Estadual Paulista (UNESP), 19060-900 Presidente Prudente, SP, Brazil 3 Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo ...
متن کاملMacrophages, fat, and the emergence of immunometabolism.
Over the last century, our modern concepts and understanding of metabolism and immunology have evolved largely in parallel. Notably, during the last decade, there has been a sharpened focus on the convergence of metabolism and immune function. In part motivated by studies originally published in the JCI, we now recognize that the immune system monitors the metabolic state of tissues and organis...
متن کاملImmunometabolism governs dendritic cell and macrophage function
Recent studies on intracellular metabolism in dendritic cells (DCs) and macrophages provide new insights on the functioning of these critical controllers of innate and adaptive immunity. Both cell types undergo profound metabolic reprogramming in response to environmental cues, such as hypoxia or nutrient alterations, but importantly also in response to danger signals and cytokines. Metabolites...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2018
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2017.11.036